De la macrocirculación hacia la microcirculación en el paciente crítico pediátrico. Una Revisión de la literatura
Resumen
El choque en pacientes pediátricos es una entidad que requiere un reconocimiento temprano y rápido con el objetivo de mejorar resultados; sin embargo, no existe un marcador definitivo y único para su detección, es por ello que los signos clínicos y los parámetros hemodinámicos ayuda a su identificación; el choque se caracteriza por una inadecuada oxigenación celular y disfunción orgánica, lo que motiva que los objetivos de la reanimación estén enfocados en normalizar variables sistémicas de la circulación y la oxigenación tisular. Si bien de forma tradicional se ha centrado la atención en parámetros relacionados con la macrocirculación, actualmente se reconoce que la microcirculación, donde ocurre el intercambio de oxígeno y de nutrientes, representa un rol esencial en la restauración celular. Para abordar esta situación, se han desarrollado herramientas de monitoreo en tiempo continuo con el objetivo de vigilar la perfusión regional y global en la cama del paciente, soportados cada vez más con estudios internacionales; dentro de estos destacan el tiempo de llenado capilar, el índice de moteado, el gradiente térmico y los niveles de lactato que ofrecen información sobre el estado de perfusión y permiten guiar la reanimación. En conclusión, integrar la evaluación de la microcirculación en el abordaje del paciente crítico pediátrico ofrece una visión más completa del estado hemodinámico, facilitando intervenciones más eficaces para mejorar la perfusión y reducir la mortalidad.
Referencias bibliográficas
Ince C. Hemodynamic coherence and the rationale for monitoring the microcirculation. Critical Care. 2015;19(S3):1-13. https://doi.org/10.1186/cc14726
Scott-L W, Mark-J P, Waleed A, Agus MS, Flori HR, Inwald DP, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr. Crit. Care Med. 2020;21(2):52-106. https://doi.org/10.1097/pcc.0000000000002198
Gupta S, Sankar J. Advances in shock management and fluid resuscitation in children. Indian J. Pediatr. 2023;90(3):280-288. https://doi.org/10.1007/s12098-022-04434-3
Singer M, Deutschmann CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801-810. https://doi.org/10.1001/jama.2016.0287
Azhibekov T, Noori S, Soleymani S, Seri I. Transitional cardiovascular physiology and comprehensive hemodynamic monitoring in the neonate: relevance to research and clinical care. Semin. Fetal Neonatal Med. 2014;19(1):45-53. https://doi.org/10.1016/j.siny.2013.09.009
Noori S, Wlodaver A, Gottipati V, McCoy M, Schultz D, Escobedo M. Transitional changes in cardiac and cerebral hemodynamics in term neonates at birth. J. Pediatr. 2012;160(6):943-948. https://doi.org/10.1016/j.jpeds.2011.12.008
Kuiper J, Tiboel D, Ince C. The vulnerable microcirculation in the critically ill pediatric patient. Critical Care. 2016;20(1). https://doi.org/10.1186/s13054-016-1496-x
Donoso-F A, Arriagada D, Cruces P, Díaz-R F. La microcirculación en el paciente crítico. Parte I: Generalidades y fisiología en el paciente séptico. Rev. chil. pediatr. 2013;84(1):83-92. https://doi.org/10.4067/S0370-41062013000100011
Jacob M, Chappell D, Becker BF. Regulation of Blood Flow and Volume Exchange across the Microcirculation. Critical Care. 2016;20(1):1-13. https://doi.org/10.1186/s13054-016-1485-0
González R, Urbano J, López-Herce J. Resuscitating the macro- vs. microcirculation in septic shock. Curr. Opin. Pediatr. 2024 mzo. 5;36(3):274-281. https://doi.org/10.1097/mop.0000000000001345
Top AP, Tasker RC, Ince C. The microcirculation of the critically ill pediatric patient. Crit Care. 2011;15(213). https://doi.org/10.1186/cc9995
Joffre J, Hellman J, Ince C, Ait-Oufella H. Endothelial responses in sepsis. Am. J. Respir. Crit. Care Med. 2020;202(3):361-370. https://doi.org/10.1164/rccm.201910-1911tr
De Backer D, Ricottilli F, Ospina-Tascón GA. Septic shock: a microcirculation disease. Curr. Opin. Anaesthesiol. 2021;34(2):85-91. https://doi.org/10.1097/aco.0000000000000957
Damiani E, Carsetti A, Casarotta E, Domizzi R, Scorcella C, Donati A, et al. Microcirculation-guided resuscitation in sepsis: the next frontier? Front. Med. 2023;10:1-6. https://doi.org/10.3389/fmed.2023.1212321
Muzaffar SN, Pradhan A, Siddiqui SS, Roy S, Suresh T. Monitoring macro- and microcirculation in the critically ill: A narrative review. Avicenna J Med. 2023;13(3):138-150. https://doi.org/10.1055/s-0043-1772175
Suchitra R, Kissoon N, Argent A, Inwald D, Cordeiro-Ventura AM, Jaborinsky R, et al. Haemodynamic support for paediatric septic shock: A global perspective. Lancet Child Adolesc Health. 2023 ago.;7(8):588-598. https://doi.org/10.1016/s2352-4642(23)00103-7
Fernández-Sarmiento J, De Souza DC, Martínez A, Nieto V, López-Herce J, Soares Lanziotti V, et al. Latin American Consensus on the management of sepsis in children: Task Force of the Sociedad Latinoamericana de Cuidados Intensivos Pediátricos (SLACIP). J Intensive Care Med. 2022 jun.;43(1):51-69. https://doi.org/10.1177/08850666211054444
Davis A, Carcillo J, Aneja R, Deymann A, Lin J, Nguyen T, et al. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Critical Care Medicine. 2017;45(6):1061-1093. https://doi.org/10.1097/ccm.0000000000002425
Mendelson J. Emergency Department Management of Pediatric Shock. Emerg Med Clin North Am. 2018 may.;36(2):427-440. https://doi.org/10.1016/j.emc.2017.12.010
Sivaprasath P, Mookka-Gounder R, Mythili B. Prediction of shock by peripheral perfusion index. Indian J Pediatr. 2019 jun. 13;86(10):903-908. https://doi.org/10.1007/s12098-019-02993-6
Shinozaki K, Saeki K, Jacobson LS, Falotico JM, Li T, Hirahara H, et al. Evaluation of accuracy of capillary refill index with pneumatic fingertip compression. J Clin Monit Comput. 2020;8. https://doi.org/10.1007/s10877-019-00454-1
He HW, Long Y, Liu DW, Ince C. Resuscitation incoherence and dynamic circulation-perfusion coupling in circulatory shock. Chin Med J (Engl). 2019 may. 20;132(10):1218-1227. https://doi.org/10.1097/cm9.0000000000000221
Lamprea S, Fernández-Sarmiento J, Barrera S, Mora A, Fernández-Sarta JP, Acevedo L. Capillary refill time in sepsis: a useful and easily accessible tool for evaluating perfusion in children. Front Pediatr. 2022 nov. 17;10. https://doi.org/10.3389/fped.2022.1035567
Lavillegrand JR, Raia L, Urbina T, Hariri G, Gabarre P, Bonny V, et al. Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients. Crit Care. 2022 ene. 21;26(1):25. https://doi.org/10.1186/s13054-022-03891-8
Huang W, Xiang H, Hu C, Wu T, Zhang D, Ma S, et al. Association of sublingual microcirculation parameters and capillary refill time in the early phase of ICU admission. Crit Care Med. 2023 jul. 1;51(7):913-923. https://doi.org/10.1097/ccm.0000000000005851
Fleming S, Gill P, Jones C, Taylor JA, Van den Bruel A, Heneghan C, et al. Validity and reliability of measurement of capillary refill time in children: A systematic review. Arch Dis Child. 2015 mzo.;100(3):239-249. https://doi.org/10.1136/archdischild-2014-307079
Merdji H, Curtiaud A, Aheto A, Studer A, Harjola VP, Monnier A, et al. Performance of early capillary refill time measurement on outcomes in cardiogenic shock: An observational, prospective multicentric study. Am J Respir Crit Care Med. 2022 nov. 15;206(10):1230-1238. https://doi.org/10.1164/rccm.202204-0687OC
Raia L, Gabarre P, Bonny V, Urbina T, Missri L, Boelle PY, et al. Kinetics of capillary refill time after fluid challenge. Annals of Intensive Care. 2022 ago. 13;12(1):74. https://doi.org/10.1186/s13613-022-01049-x
Chandra J, Armengol de la Hoz MA, Lee G, Lee A, Thoral P, Elbers P, et al. A novel vascular leak index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation. Crit Care. 2022 abr. 11;26(1):103. https://doi.org/10.1186/s13054-022-03968-4
Hernández G, Ospina-Tascón GA, Damiani LP, Estenssoro E, Dubin A, Hurtado J, et al. Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock. JAMA. 2019 feb. 17;321(7):654-664. https://doi.org/10.1001/jama.2019.0071
Lamprea S, Fernández-Sarmiento J, Barrera S, Mora A, Fernández-Sarta JP, Acevedo L. Capillary refill time in sepsis: a useful and easily accessible tool for evaluating perfusion in children. Front Pediatr. 2022 nov. 17;10. https://doi.org/10.3389/fped.2022.1035567
Bakker J, Hernandez G. Can peripheral skin perfusion be used to assess organ perfusion and guide resuscitation interventions? Front Med. 2020 jun. 23;7. https://doi.org/10.3389/fmed.2020.00291
Ait-Oufella H, Bige N, Boelle PY, Pichereau C, Alves M, Bertinchamp R, et al. Capillary refill time exploration during septic shock. Intensive Care Med. 2014 jul.;40(7):958-964. https://doi.org/10.1007/s00134-014-3326-4
Nazir M, Wani W, Dar SA, Mir IH, Charoo BA, Ahmad QI, et al. Lactate clearance prognosticates outcome in pediatric septic shock during first 24h of intensive care unit admission. J Intensive Care Soc. 2019 nov.;20(4):290-298. https://doi.org/10.1177/1751143719855202
Scott HF, Brou L, Deakyne SJ, Fairclough DL, Kempe A, Bajaj L, et al. Lactate clearance and normalization and prolonged organ dysfunction in pediatric sepsis. J Pediatr. 2016 mzo.;170:149-155. https://doi.org/10.1016/j.jpeds.2015.11.071
Lima A, Bakker J. Clinical assessment of peripheral circulation. Curr Opin Crit Care. 2025 jun.;21(3):226-231. https://doi.org/10.1097/MCC.0000000000000194
Bourcier S, Pichereau C, Boelle PY, Nemlaghi S, Dubée V, Lejour G, et al. Toe-To-Room Temperature Gradient Correlates with Tissue Perfusion and Predicts Outcome in Selected Critically Ill Patients with Severe Infections. Ann Intensive Care. 2016 dic.;6(1):63. https://doi.org/10.1186/s13613-016-0164-2
Ait-Oufella H, Lemoinne S, Boelle PY, Galbois A, Baudel JL, Lemant J, et al. Mottling score predicts survival in septic shock. Intensive Care Med. 2011;37(5):801-807. https://doi.org/10.1007/s00134-011-2163-y
de Moura EB, Amorim FF, da Cruz Santana AN, Kanhouche G, de Souza Godoy LG, de Jesus Almeida L, et al. Skin mottling score as a predictor of 28-day mortality in patients with septic shock. Intensive Care Med. 2016 mzo.;42(3):479-480. https://doi.org/10.1007/s00134-015-4184-4


